The 22-year-old was enjoying the best run of her career in Rome after reaching the round of 16 for the first time.
Emma Raducanu was feeling confident about her game after winning two tough three-set matches and securing a comprehensive 6-2, 6-2 victory to reach the fourth round.
But Coco Gauff proved too high a hurdle for the Brit to overcome as the American sailed into the quarter-finals with an emphatic win.
Emma Raducanu praises Coco Gauff’s performance after losing to her in Rome
Gauff and Raducanu played for just the second time in their careers at the Italian Open on Monday. This was their first meeting since Gauff claimed a 6-3 7-6(4) victory at the 2023 Australian Open.
Their clash at the Foro Italico was a more one-sided affair as Gauff won 6-1, 6-2 and became the youngest player to reach four quarterfinals in clay WTA 1000 events since the format began in 2009.
Raducanu struggled to make an impression, hitting just nine winners and committed 19 unforced errors during the contest.
Despite admitting to struggling with the conditions the former British number one praised the performance from Gauff, who has won her last six sets after losing the opening set in her first match.
“I found it a really difficult match. I think the conditions were very different from my last round. It was a different court and it was very bouncy. It was quite windy too,” Raducanu told Sky Sports.